KMID : 0358320150560060435
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Korean Journal of Urology 2015 Volume.56 No. 6 p.435 ~ p.442
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Two-dimensional neovascular complexity is significantly higher in nontumor prostate tissue than in low-risk prostate cancer
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Taverna Gianluigi
Grizzi Fabio Colombo Piergiuseppe Seveso Mauro Giusti Guido Proietti Silvia Fiorini Girolamo Lughezzani Giovanni Casale Paolo Buffi Nicolo Lazzari Massimo Guazzoni Giorgio
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Abstract
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Purpose: Prostate cancer is the most frequent cancer in men in Europe. A major focus in urology is the identification of new biomarkers with improved accuracy in patients with low-risk prostate cancer. Here, we evaluated two-dimensional neovascular complexity in prostate tumor and nontumor biopsy cores by use of a computer-aided image analysis system and assessed the correlations between the results and selected clinical and pathological parameters of prostate carcinoma.
Materials and Methods: A total of 280 prostate biopsy sections from a homogeneous series of 70 patients with low-risk prostate cancer (Gleason score 3+3, prostate-specific antigen [PSA]<10 ng/mL, and clinical stage T1c) who underwent systematic biopsy sampling and subsequent radical prostatectomy were analyzed. For each biopsy, 2-¥ìm sections were treated with CD34 antibodies and were digitized by using an image analysis system that automatically estimates the surface fractal dimension.
Results: Our results showed that biopsy sections without cancer were significantly more vascularized than were tumors. No correlations were found between the vascular surface fractal dimension and patient¡¯s age, PSA and free-to-total PSA ratios, pathological stage, Gleason score, tumor volume, vascular invasion, capsular penetration, surgical margins, and biochemical recurrence.
Conclusions: The value of angiogenesis in prostate cancer is still controversial. Our findings suggest that low-risk prostate cancer tissues are less vascularized than are nontumor tissues. Further studies are necessary to understand whether angiogenesis is a hallmark of intermediate- and high-risk prostate cancer.
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KEYWORD
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Biological markers , Blood vessels , Neoplasms , Prostate
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